Who Decided How Big a Tablet Should Be?
The hidden engineering behind every pill you’ve ever taken The size of a tablet feels like a design decision. It isn’t. It […]
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Naproxen: A Case Study in Conservative Formulation
When a superior molecule is held back by its delivery system Naproxen’s long-lasting effect is well known. Its slow start is the […]
Read moreThe End of the Tablet Era
The best-selling drug in the world is no longer a tablet. The pipeline behind it is no longer led by small molecules. […]
Read morePharma Optimised for Factories, Not Humans
The compressed tablet was a 19th-century manufacturing fix. It became the unquestioned default of modern medicine. Modern medicine can design a molecule […]
Read moreWhy Are Pills Round?
The shape of the most-produced manufactured object in human history was decided in 1843. The patient was never in the room. The […]
Read moreThe 80% Problem
Why the most consequential number in pharma is the one nobody says out loud Ninety-nine of every hundred milligrams in the most […]
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Bioavailability Is Pharma’s Dirty Secret
The Illusion of Effectiveness The single number that decides whether a medicine works. The one number patients are never told. (7-minute read) […]
Read moreStandard Dosing Is Fundamentally Broken
One Dose. Millions of Bodies. A single tablet is designed to deliver: The same dose to everyone. Regardless of: This is not […]
Read moreWhy Ibuprofen Works Better Than It Should
The Molecule That Accidentally Exposed the Limits of the Tablet Swallow a standard ibuprofen tablet for a headache, and for the next […]
Read moreWhy Are Some Pills Oval?
The Moment Medicine Started Bending Toward the Human Body There is a quiet shift hidden inside the oval pill. At first glance, […]
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