Two Roads to One Pill
Ozempic is a pill now, but oral bioavailability wasn’t solved. How Novo Nordisk and Eli Lilly reached comparable results by two opposite routes.
Read moreTag: drug delivery
The Third Battle, Better on Paper
A 2020 mouse study hit an oral bioavailability no approved oral peptide drug has matched in a human. Why lipid-based delivery — […]
Read moreThe Colour of Taste
Why a red syrup tastes sweeter before it’s swallowed: the psychology of colour, taste and liquid medicine, from Ibumix.
Read moreThe Second Battle, Opened From the Inside
The Second Battle, Opened From the Inside Octreotide, acromegaly and the tight-junction trick that takes on the gut wall directly Rybelsus proved […]
Read moreWho Decided How Big a Tablet Should Be?
The hidden engineering behind every pill you’ve ever taken The size of a tablet feels like a design decision. It isn’t. It […]
Read moreNaproxen: A Case Study in Conservative Formulation
When a superior molecule is held back by its delivery system Naproxen’s long-lasting effect is well known. Its slow start is the […]
Read moreThe End of the Tablet Era
The best-selling drug in the world is no longer a tablet. The pipeline behind it is no longer led by small molecules. […]
Read moreA polysorbate cannot do this alone
Why both small-molecule solubility and biologic stability hit ceilings the surfactant cannot raise — and what an engineered architecture changes. Polysorbates 20 […]
Read moreMedicine in Free Fall
Why pharmaceutical science is heading to orbit From cancer antibodies that crystallise more cleanly 400 kilometres above the Earth, to autonomous capsules […]
Read morePharma Optimised for Factories, Not Humans
The compressed tablet was a 19th-century manufacturing fix. It became the unquestioned default of modern medicine. Modern medicine can design a molecule […]
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