Why Are Pills Round?
The shape of the most-produced manufactured object in human history was decided in 1843. The patient was never in the room. The […]
Read moreTag: bioavailability
The 80% Problem
Why the most consequential number in pharma is the one nobody says out loud Ninety-nine of every hundred milligrams in the most […]
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Bioavailability Is Pharma’s Dirty Secret
The Illusion of Effectiveness The single number that decides whether a medicine works. The one number patients are never told. (7-minute read) […]
Read moreAI Designed the Molecule. It Still Failed the Patient.
Drug Delivery as the Missing Layer in the AI-Enabled Pharmaceutical Stack Abstract Artificial intelligence (AI) is reshaping pharmaceutical research by accelerating target […]
Read morePharma Optimised for Factories, Not Humans
The System Was Designed Backwards Modern medicine looks advanced. Precision molecules. Billion-dollar trials. AI-driven discovery. And yet, when the drug finally reaches […]
Read moreStandard Dosing Is Fundamentally Broken
One Dose. Millions of Bodies. A single tablet is designed to deliver: The same dose to everyone. Regardless of: This is not […]
Read moreThe End of the Tablet Era
Every Industry Has a Legacy Format Each was once dominant.Each became obsolete. Pharma has its own legacy format: The tablet. Why It […]
Read moreWhy Ibuprofen Works Better Than It Should
The Molecule That Accidentally Exposed the Limits of the Tablet The Exception That Became the Standard In a world where many drugs […]
Read moreNaproxen: A Case Study in Conservative Formulation
When a Great Molecule Is Held Back by Its Delivery System The Paradox of Naproxen Naproxen is, in many ways, a superior […]
Read moreWho Decided How Big a Tablet Should Be?
The Hidden Engineering Behind Every Pill You’ve Ever Taken You’ve felt it before. That moment when a tablet feels just slightly too […]
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