Soluble and Impermeable
Why an oral peptide delivers about one per cent of its dose – and what the tablet has to carry to manage even that.
Read moreTag: bioavailability
Two Roads to One Pill
Ozempic is a pill now, but oral bioavailability wasn’t solved. How Novo Nordisk and Eli Lilly reached comparable results by two opposite routes.
Read moreThe Third Battle, Better on Paper
A 2020 mouse study hit an oral bioavailability no approved oral peptide drug has matched in a human. Why lipid-based delivery — […]
Read moreThe Second Battle, Opened From the Inside
The Second Battle, Opened From the Inside Octreotide, acromegaly and the tight-junction trick that takes on the gut wall directly Rybelsus proved […]
Read moreWho Decided How Big a Tablet Should Be?
The hidden engineering behind every pill you’ve ever taken The size of a tablet feels like a design decision. It isn’t. It […]
Read moreNaproxen: A Case Study in Conservative Formulation
When a superior molecule is held back by its delivery system Naproxen’s long-lasting effect is well known. Its slow start is the […]
Read moreThe End of the Tablet Era
The best-selling drug in the world is no longer a tablet. The pipeline behind it is no longer led by small molecules. […]
Read moreBeyond Dissolution: Reframing Lipid Functionality
Why the next chapter in oral drug delivery is being written by lipids — and not the ones you think. Lipid-based delivery […]
Read morePharma Optimised for Factories, Not Humans
The compressed tablet was a 19th-century manufacturing fix. It became the unquestioned default of modern medicine. Modern medicine can design a molecule […]
Read moreWhy Are Pills Round?
The shape of the most-produced manufactured object in human history was decided in 1843. The patient was never in the room. The […]
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