The Ordered Liquid: potassium cinnamate, GCC and the liquid crystal beneath Cinnamix
A liquid crystal is a paradox — a fluid that flows like a liquid yet holds internal order like a crystal. Cinnamix […]
Read moreAuthor: George Forrest
Naproxen: A Case Study in Conservative Formulation
When a superior molecule is held back by its delivery system Naproxen’s long-lasting effect is well known. Its slow start is the […]
Read moreThe End of the Tablet Era
The best-selling drug in the world is no longer a tablet. The pipeline behind it is no longer led by small molecules. […]
Read moreA polysorbate cannot do this alone
Why both small-molecule solubility and biologic stability hit ceilings the surfactant cannot raise — and what an engineered architecture changes. Polysorbates 20 […]
Read moreBeyond Dissolution: Reframing Lipid Functionality
Why the next chapter in oral drug delivery is being written by lipids — and not the ones you think. Lipid-based delivery […]
Read moreMedicine in Free Fall
Why pharmaceutical science is heading to orbit From cancer antibodies that crystallise more cleanly 400 kilometres above the Earth, to autonomous capsules […]
Read morePharma Optimised for Factories, Not Humans
The compressed tablet was a 19th-century manufacturing fix. It became the unquestioned default of modern medicine. Modern medicine can design a molecule […]
Read moreAlmost 100% Absorbed. Almost Always Late.
Why ibuprofen is the cleanest test case in the world for a new generation of drug delivery — and the molecule on […]
Read moreWhy Are Pills Round?
The shape of the most-produced manufactured object in human history was decided in 1843. The patient was never in the room. The […]
Read moreThe 80% Problem
Why the most consequential number in pharma is the one nobody says out loud Ninety-nine of every hundred milligrams in the most […]
Read more